Clinical inquiries: what is the role of prokinetic agents for constipation?

Managing Opioid-Induced Constipation in Ambulatory-Care Patients

Introduction ..................................................... 1 Functional Constipation .................................. 2 Opioid-Induced Constipation........................... 2 Prevalence .................................................. 3 Role of Opioid Receptors............................ 3 Differential Opioid Effects ........................... 3 Patient Assessment & Treatment......

Does Achillea millefolium extracts possess prokinetic effects on the bovine abomasum thourgh M3 muscarinic receptors?

Displacement of the abomasum is a common disease of the gastrointestinal tract in dairy cattle. Abomasal displacement has been associated with abomasal hypomotility. Therefore, it is necessary to identify effective therapeutic agents that stimulate abomasal motility in cattle. Yarrow (Achillea millefolium) is traditionally used as a folk remedy for treatment of human gastrointestinal c...

Clinical inquiries. What treatments work best for constipation in children?

Osmotic laxatives produce the best results. Fiber and behavior modification may have a role. Increased fiber and behavior modification are the most often recommended first steps in managing chronic functional constipation (CFC) in children, but only limited evidence supports this approach. For pharmacologic management, the best evidence supports osmotic laxatives.

Herbal Formula Modified Buzhong-Yiqi-Tang for Functional Constipation in Adults: A Meta-Analysis of Randomized Controlled Trials

Background Herbal formula Modified Buzhong-Yiqi-Tang (MBYT) has been widely used for the treatment of functional constipation in East Asia, but its efficacy and safety are unclear. Methods The study was to evaluate the efficacy and safety of MBYT for adult patients with functional constipation. Randomized clinical trials were selected according to predefined inclusion and exclusion criteria. ...

Clinical inquiries. What is the most effective way for relieving constipation in children aged >1 year?